Hydrochloric Acid → 1-(4-isopropoxyphenyl)propan-2-one

HRID 1731583노트

반응식

HRID 1731583 반응식
Cl.[CH:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]=[C:13]([N+]([O-])=O)[CH3:14])=[CH:8][CH:7]=1)([CH3:4])[CH3:3].[O:18]1CCCC1>[Fe]>[CH:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13](=[O:18])[CH3:14])=[CH:8][CH:7]=1)([CH3:4])[CH3:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 541717311-(1-Methylethoxy)-4-(2-nitro-1-propen-1-yl)benzene

생성물 1

HCID 9193321-(4-isopropoxyphenyl)propan-2-one

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

Concentrated hydrochloric acid (90 ml) was added dropwise, over 45 minutes, to a stirred mixture of iron powder (17.5 g) and 1-(4-isopropoxyphenyl)-2-nitroprop1-ene (16.0 g) in tetrahydrofuran (50 ml) at reflux. The mixture was heated under reflux for a further hour, cooled, filtered through diatomaecous earth and the tetrahydrofuran removed under reduced pressure. The residue was diluted with water, extracted with diethyl ether, washed with brine, dried (magnesium sulphate), filtered and evaporated to dryness. Distillation of the residue gave the title compound, bp 120°-6°/1.5 mm.

후처리

  1. temperatureat reflux
  2. temperatureThe mixture was heated
  3. temperatureunder reflux for a further hour
  4. temperaturecooled
  5. filtrationfiltered through diatomaecous earth
  6. customthe tetrahydrofuran removed under reduced pressure
  7. additionThe residue was diluted with water
  8. extractionextracted with diethyl ether
  9. washwashed with brine
  10. dry with materialdried (magnesium sulphate)
  11. filtrationfiltered
  12. customevaporated to dryness
  13. distillationDistillation of the residue

출처 및 근거

ORD 기록
ord-c20dbfec2e004b3f8259191b0db34ffc
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04622342

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