Cerium(III) chloride → HCID 54572386, 화합물

HRID 1731651노트

반응식

HRID 1731651 반응식
[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:4]=[CH:3]1.[Cl-].[Ce+3].[Cl-].[Cl-].[BH4-].[Na+]>CO>[OH:1][CH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:4]=[CH:3]1

참가 물질

5

반응물 3

HCID 24636Cerium(III) chlorideHCID 4311764Sodium borohydrideHCID 14430179HCID 14430179, 화합물

생성물 1

HCID 54572386HCID 54572386, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of 0.36 g of methyl 4-oxocyclohex-2-enepropionate and 500 ml of 0.4M cerium chloride in methanol there was added carefully 0.07 g of sodium borohydride and the mixture was stirred for 10 minutes at room temperature. The reaction was quenched with 2 ml of water and the methanol solvent was removed under reduced pressure. The residue was partitioned between 10 ml of water and 50 ml of ether and the separated organic layer was dried over magnesium sulfate. Evaporation of the solvent from the organic solution gave methyl 4-hydroxycyclohex-2-enepropionate as a clear oil which was used without further purification. 1H NMR (CDCl3) δ 3.56 (s, 3H); 3.90-4.30 (m, 1H); 5.50-5.75 (m, 2H).

후처리

  1. customThe reaction was quenched with 2 ml of water
  2. customthe methanol solvent was removed under reduced pressure
  3. customThe residue was partitioned between 10 ml of water and 50 ml of ether
  4. dry with materialthe separated organic layer was dried over magnesium sulfate
  5. customEvaporation of the solvent from the organic solution

출처 및 근거

ORD 기록
ord-18b35497b407447c86fa0e9444abbf6c
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04622422

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