Propanenitrile, 3-ethoxy- → HCID 13496625, 화합물

HRID 1731652

반응식

HRID 1731652 반응식
[Na].[NH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)[NH2:3].C(O[CH2:13][CH2:14][C:15]#[N:16])C>C(O)C>[NH2:16][C:15]1[CH2:14][CH2:13][N:2]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 16501Propanenitrile, 3-ethoxy-HCID 786452-HydrazinopyridineHCID 5360545Sodium

생성물 1

HCID 13496625HCID 13496625, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A 0.58 g. amount of sodium metal is dissolved in 150 ml. of absolute ethanol, then 14.0 g. of 2-hydrazinopyridine is added followed by 12.7 g. of betaethoxypropionitrile. The reaction mixture is refluxed on a steam bath for 16 hours, then the solvent is removed in vacuo. Water is added and the solid collected by filtration. The solid is recrystallized twice from acetone to give 5.55 g. of the product of the Example as tan colored crystals, m.p. 168.5°-171° C.

후처리

  1. temperatureThe reaction mixture is refluxed on a steam bath for 16 hours
  2. customthe solvent is removed in vacuo
  3. additionWater is added
  4. filtrationthe solid collected by filtration
  5. customThe solid is recrystallized twice from acetone
  6. customto give 5.55 g

출처 및 근거

ORD 기록
ord-4e67e853bdf443e5ae26b09991027a76
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04622401

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