Choline → HCID 20228180, 화합물

HRID 1731661

반응식

HRID 1731661 반응식
C(O[CH2:4][CH2:5][C:6]#[N:7])C.C(O)C.[NH:11]([C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)[NH2:12].OCC[N+](C)(C)C>CO>[NH2:7][C:6]1[CH2:5][CH2:4][N:11]([C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[N:12]=1

참가 물질

6

반응물 4

HCID 305CholineHCID 702EthanolHCID 119882-Benzothiazolinone, hydrazoneHCID 16501Propanenitrile, 3-ethoxy-

생성물 1

HCID 20228180HCID 20228180, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 5.0 g. of β-ethoxypropionitrile, 100 ml. of absolute ethanol, 8.25 g. of 2-hydrazinobenzothiazole and 2.5 g. of 50% w/v choline in methanol is refluxed on a steam bath for 16 hours, then the solvent is removed in vacuo. Water is added and the solid is collected by filtration. The solid is recrystalized twice from ethanol to give 5.75 g. of the product of the Example as grey prisms, m.p. 231.5°-235° C.

후처리

  1. additionA mixture of 5.0 g
  2. temperatureis refluxed on a steam bath for 16 hours
  3. customthe solvent is removed in vacuo
  4. additionWater is added
  5. filtrationthe solid is collected by filtration
  6. customThe solid is recrystalized twice from ethanol
  7. customto give 5.75 g

출처 및 근거

ORD 기록
ord-96eb4ec0f63c4844ba66b37c8d009237
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04622401

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