Hydrochloric Acid → N-heptyl-4-butylbenzenemethanamine

HRID 1731852

반응식

HRID 1731852 반응식
[CH2:1]([NH:8][C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Cl>O1CCCC1>[CH2:1]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 13733121Benzamide, 4-butyl-N-heptyl-

생성물 1

HCID 15137718N-heptyl-4-butylbenzenemethanamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 38.0 g of N-heptyl-4-n-butylbenzamide and 280 ml of borane-tetrahydrofuran complex in 120 ml of anhydrous tetrahydrofuran was refluxed for 18 hours, allowed to cool, and treated with 6N hydrochloric acid. The organic solvent was evaporated and the residue was partitioned between ether and aqueous sodium hydroxide solution. The ether layer was separated, dried, and evaporated. The residue was distilled to yield N-heptyl-4-n-butylbenzenemethanamine as a colorless liquid, bp 115° C. at 80μ.

후처리

  1. temperatureto cool
  2. customThe organic solvent was evaporated
  3. customthe residue was partitioned between ether and aqueous sodium hydroxide solution
  4. customThe ether layer was separated
  5. customdried
  6. customevaporated
  7. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-bf5ed8ed898c4da5ae774386f939729f
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04623662

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