Ethyl orthoformate → HCID 13385702, 화합물

반응식

[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][C:6]([F:15])=[C:7]([F:14])[CH:8]=2)[N:3]=1.[CH:16](OCC)(OCC)OCC>>[Cl:1][C:2]1[C:11]2[N:10]([CH:16]=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][C:6]([F:15])=[C:7]([F:14])[CH:8]=2

참가 물질

반응물 2

HCID 31214Ethyl orthoformate

HCID 133856772-Chloro-6,7-difluoro-3-hydrazinoquinoxaline

생성물 1

HCID 13385702HCID 13385702, 화합물

실험 절차

A mixture consisting of 5.99 g. (0.026 mole) of 2-chloro-6,7-difluoro-3-hydrazinoquinoxaline and 30 ml. (0.18 mole) of triethyl orthoformate was heated at 100° C. for a period of 24 hours to give a red-brown solid. The resulting slurry was then cooled to room temperature and filtered, and the recovered product subsequently washed with diethyl ether to ultimately afford 5.15 g. (82%) of pure 4-chloro-7,8-difluoro-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. >210° C. (decomp.). Mass Spectrum: m/e, 242/240 (P+).

후처리

customto give a red-brown solid
filtrationfiltered
washthe recovered product subsequently washed with diethyl ether to ultimately afford 5.15 g

출처 및 근거

ORD 기록: ord-9aa25f5c89804e75bc950ca8d532fccd
출처 데이터셋: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04623725

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