Piperidin-4-ol → CM 40907

HRID 1731994노트

반응식

HRID 1731994 반응식
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[Cl:14])=[CH:6][CH:7]=1.[OH:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(O)CCC>[OH:15][CH:16]1[CH2:21][CH2:20][N:19]([C:2]2[N:3]=[N:4][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[Cl:14])=[CH:6][CH:7]=2)[CH2:18][CH2:17]1

참가 물질

4

반응물 2

HCID 79341Piperidin-4-olHCID 124495573-Chloro-6-(2-chlorophenyl)pyridazine

생성물 1

HCID 65835CM 40907

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

Operation is carried out in accordance with the methods mentioned for preparing 3-chloro-6-(2-chloro-phenyl)pyridazine (m.p.: 146°-147° C.). 5 g of this product are dissolved in 120 ml of normal butanol and mixed with 6.74 g of 4-hydroxy-piperidine, then heated to reflux. By following the modus operandi described for the previous Example, 5 g of CM 40907 are obtained after recrystallization in absolute ethanol.

후처리

  1. temperatureheated to reflux
  2. customare obtained
  3. customafter recrystallization in absolute ethanol

출처 및 근거

ORD 기록
ord-a945df9f5f7e42959e7e4eea044dc266
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04624952

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