N-bromobutanimide → 5-(Bromomethyl)-α-methyl-2-nitrobenzenemethanol

HRID 1732078노트

반응식

[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1.[Br:14]N1C(=O)CCC1=O>>[Br:14][CH2:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:8]([OH:10])[CH3:9])[CH:7]=1

참가 물질

반응물 2

HCID 67184N-bromobutanimide

HCID 11769120HCID 11769120, 화합물

생성물 1

HCID 202265155-(Bromomethyl)-α-methyl-2-nitrobenzenemethanol

실험 절차

Compound 2 is synthesized in two steps from 1-(5-methyl-2-nitrophenyl) ethanone (1), which can be obtained as described by Doppler et al. (1979) Helv. Chem. Acta 62:291-303. Specifically, the ring methyl group is brominated using N-bromosuccinimide and then the benzylic ketone is reduced to an alcohol. Those procedures are described below.

후처리

customcan be obtained

출처 및 근거

ORD 기록: ord-4b37a79c79a94d5bb2f61fd5cc7a7955
출처 데이터셋: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04625014

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