Phosphorus oxychloride → 2-Chloro-6-fluoroquinoline

HRID 1732187노트

반응식

HRID 1732187 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[CH:6]=[CH:5]2.P(Cl)(Cl)([Cl:15])=O>>[Cl:15][C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)[N:8]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 98340436-Fluoro-1,2-dihydroquinolin-2-one

생성물 1

HCID 150594332-Chloro-6-fluoroquinoline

실험 절차

A mixture of the so-prepared 6-fluorocarbostyril (2.9 gm, 0.018 mole) and 30.0 ml of phosphorous oxychloride was refluxed for 1.5 hr. Most of the excess phosphorous oxychloride was then distilled off under aspirator vacuum and the residue poured over crushed ice. The reaction mixture was made nearly neutral with 50% sodium hydroxide. The crude solid product was collected by filtration, taken up in

후처리

  1. temperaturewas refluxed for 1.5 hr
  2. distillationMost of the excess phosphorous oxychloride was then distilled off under aspirator vacuum
  3. additionthe residue poured
  4. customover crushed ice
  5. filtrationThe crude solid product was collected by filtration

출처 및 근거

ORD 기록
ord-0793f36da021490f8ff5dd1a0618968b
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04236912

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