Sodium Bicarbonate → 6-Methyl-6-hepten-2-one

HRID 1732264노트

반응식

HRID 1732264 반응식
C1CO[C:3]([CH3:10])([CH2:4][CH2:5][CH2:6][C:7]([CH3:9])=[CH2:8])[O:2]1.C(=O)(O)[O-].[Na+]>CC(C)=O.Cl>[CH3:9][C:7]([CH2:6][CH2:5][CH2:4][C:3](=[O:2])[CH3:10])=[CH2:8]

참가 물질

5

반응물 2

HCID 516892Sodium BicarbonateHCID 10975921HCID 10975921, 화합물

생성물 1

HCID 1515096-Methyl-6-hepten-2-one수율 70.8%

시약·촉매·용매 2

HCID 180Acetone용매HCID 313Hydrochloric Acid용매

실험 절차

A solution of 6,6-ethylenedioxy-2-methyl-hept-1-ene (12.2 g) in acetone (300 ml) and 10% hydrochloric acid (12 ml) is stirred at room temperature for 1.5 hours. The reaction is neutralized to pH 7 with a sodium bicarbonate solution and the resulting solids are filtered. The acetone is removed in vacuo and the residue is partitioned between ether and brine. The ether extract is dried (Na2SO4) and evaporated in vacuo to give 2-methyl-6-oxo-hept-1-ene as a pale yellow liquid (6.4 g): nmr (CDCl3,δ) 1.7 (br s, CH3 --C=), 2.12 (s, CH3C=O), 2.4 (t, J=6 Hz, CH2C=O), 4.69 (br s, 2H, H2C=C).

후처리

  1. filtrationthe resulting solids are filtered
  2. customThe acetone is removed in vacuo
  3. customthe residue is partitioned between ether and brine
  4. extractionThe ether extract
  5. dry with materialis dried (Na2SO4)
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-ec02f71371804ef484c4447e6bff4f18
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04237055

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