Diboron → 3-Hydroxymethyl-10,11-dihydrodibenzo[b,f]thiepin
반응식
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[S:6][C:5]=2[CH:4]=[C:3]([C:16](O)=[O:17])[CH:2]=1.B#B>O1CCCC1.O>[OH:17][CH2:16][C:3]1[CH:2]=[CH:1][C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[S:6][C:5]=2[CH:4]=1참가 물질
5
실험 절차
Dissolve 7.5 gm. of 10,11-dihydrodibenzo[b,f]-thiepin-3-carboxylic acid in 140 ml. of tetrahydrofuran. With stirring, add 90 ml. of 1 N diborane in tetrahydrofuran. Stir at room temperature for 2 hours and dilute the reaction mixture with water. Extract into ether, and evaporate the ether extract to dryness. Stir the residue with hexane and filter to obtain the title product (m.p., 82°-84° C.).
후처리
- dissolutionDissolve 7.5 gm
- additionadd 90 ml
- stirringStir at room temperature for 2 hours
- extractionExtract into ether
- customevaporate the ether
- extractionextract to dryness
- stirringStir the residue with hexane
- filtrationfilter
출처 및 근거
- ORD 기록
- ord-b0b2b82bec164028997e437c011ae2bf
- 출처 데이터셋
- uspto-grants-1980_12
- 특허 번호
- US04237160
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