Hydrochloric Acid → HCID 178426111, 화합물

HRID 1732384

반응식

HRID 1732384 반응식
C[O-:2].[Na+].[Na].NO.Cl.C[N:9](C)[CH:10]=[N:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=1[CH3:19]>CO.O>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([NH:11][CH:10]=[N:9][OH:2])=[C:13]([CH3:19])[CH:14]=1

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 22544ChlordimeformHCID 5360545SodiumHCID 10942334Sodium Methoxide

생성물 1

HCID 178426111HCID 178426111, 화합물

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 962Water용매

실험 절차

To a sodium methoxide solution prepared by dissolving 19 grams of sodium metal in 250 milliliters of methanol was added 56 grams of hydroxylamine:hydrochloride in 300 milliliters of methanol. To the resulting mixture was added 98 grams (0.5 mole) of N,N-dimethyl-N'-(4-chloro-2-methylphenyl)methanimidamide. The mixture was stirred at room temperature for 18 hours. The solid reaction product was recovered by filtration and the filtrate concentrated by evaporation under reduced pressure. The residue and the solid reaction product (filter cake) were suspended in water, collected by filtration, water washed and recrystallized from ethanol. The N-(4-chloro-2-methylphenyl)-N'-hydroxymethanimidamide product was recovered in a yield of 81.7 grams (89% of theoretical) and melted at 171°-171.5° C.

후처리

  1. customThe solid reaction product
  2. filtrationwas recovered by filtration
  3. concentrationthe filtrate concentrated by evaporation under reduced pressure
  4. customThe residue and the solid reaction product (filter cake)
  5. filtrationcollected by filtration, water
  6. washwashed
  7. customrecrystallized from ethanol
  8. customThe N-(4-chloro-2-methylphenyl)-N'-hydroxymethanimidamide product was recovered in a yield of 81.7 grams (89% of theoretical) and melted at 171°-171.5° C.

출처 및 근거

ORD 기록
ord-dbd04e5c2d42444180cea3c79f92479a
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04237168

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