Hydrogen Bromide → HCID 5323829, 화합물

HRID 1732858노트

반응식

HRID 1732858 반응식
[CH3:1][C:2]12[CH:9](O)[C:6]([CH3:11])([CH2:7][CH2:8]1)[CH2:5][CH2:4][CH2:3]2.[BrH:12]>>[CH3:1][C:2]12[CH:9]([Br:12])[C:6]([CH3:11])([CH2:7][CH2:8]1)[CH2:5][CH2:4][CH2:3]2

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 1084411,5-Dimethylbicyclo[3.2.1]octan-8-ol

생성물 1

HCID 5323829HCID 5323829, 화합물수율 85.1%

실험 절차

1,5-dimethyl-8-hydroxy bicyclo[3,2,1]octane (13.6 g (0.1 mol)) was boiled with 50 ml 48% hydrogen bromide for 4 hours under stirring in the presence of 1 g AMBERLYST A15 ion-exchange resin. The reaction product was extracted after cooling with pentane. The pentane layer was washed with water and a diluted sodium bicarbonate solution. After drying over anhydrous sodium sulfate and boiling down pentane the residue was subjected to fractional distillation under reduced pressure. 18.5 g 1,5-dimethyl-8-bromobicyclo[3,2,1]octane was obtained in 85.1% yield (b.p. 93° C./10 mm Hg). The product obtained was identical with the compound according to the process described in Example 2a.

후처리

  1. extractionThe reaction product was extracted
  2. temperatureafter cooling with pentane
  3. washThe pentane layer was washed with water
  4. dry with materialAfter drying over anhydrous sodium sulfate
  5. distillationwas subjected to fractional distillation under reduced pressure

출처 및 근거

ORD 기록
ord-971ba37469444c3c91e3311e2dce7b17
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04239707

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