Ethyl Bromide → N-Ethyl-N-methyl-2-thiophene methanamine

HRID 1732894

반응식

HRID 1732894 반응식
BrCC.[CH2:4]([N:6]([CH2:9][CH3:10])[CH2:7][CH3:8])C.CNC[C:14]1[S:15]C=[CH:17][CH:18]=1>C1(C)C=CC=CC=1.O.C(=O)(O)[O-].[Na+]>[CH2:7]([N:6]([CH3:4])[CH2:9][C:10]1[S:15][CH:14]=[CH:18][CH:17]=1)[CH3:8]

참가 물질

7

반응물 3

HCID 6332Ethyl BromideHCID 8471TriethylamineHCID 436153N-Methyl-1-(thiophen-2-yl)methanamine

생성물 1

HCID 12788071N-Ethyl-N-methyl-2-thiophene methanamine

시약·촉매·용매 3

HCID 962Water용매HCID 1140Toluene용매HCID 516892Sodium Bicarbonate용매

실험 절차

Bromoethane (150 ml), triethylamine (7.3 ml) and N-methyl-2-thiophenemethanamine (21.2 g) were stirred at room temperature in toluene (212 ml) for 4 days. The solution was diluted with water, saturated with sodium bicarbonate and extracted with ethyl acetate. The organic extracts were distilled to give the title compound as an oil (13.6 g) b.p. 46° (16 mm).

후처리

  1. extractionextracted with ethyl acetate
  2. distillationThe organic extracts were distilled

출처 및 근거

ORD 기록
ord-2cc545f257c747f1846a3e4260f3340f
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04239769

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