Acetic Acid → HCID 20300371, 화합물

HRID 1733148노트

반응식

HRID 1733148 반응식
[NH2:1][C:2]1[O:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8].[C:13](O)(=[O:15])[CH3:14].C(OC(=O)C)(=O)C>>[C:13]([NH:1][C:2]1[O:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8])(=[O:15])[CH3:14]

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 13770581HCID 13770581, 화합물

생성물 1

HCID 20300371HCID 20300371, 화합물수율 83.4%

실험 절차

16.4 g (0.1 mole) of 2-amino-3-cyano-4-tert.-butylfuran were heated to 100° C. with 24 ml (0.4 mole) of acetic acid and 10.4 ml (0.11 mole) of acetic anhydride for one hour. Thereafter, the reaction mixture was evaporated under reduced pressure and the residue was recrystallized from a mixture of toluene/cyclohexane (1:2). 17.2 g of 2-acetylamino-3-cyano-4-tert.-butyl-furan of melting point 135° C. were obtained in this manner.

후처리

  1. customThereafter, the reaction mixture was evaporated under reduced pressure
  2. customthe residue was recrystallized from a mixture of toluene/cyclohexane (1:2)

출처 및 근거

ORD 기록
ord-906e8f6c272a4d838725e739580d17b5
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04240820

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