Acetic Acid → 2-Propenal, 3-[4-(1,1-dimethylethyl)phenyl]-2-methyl-

HRID 1733271

반응식

HRID 1733271 반응식
[C:1]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[K+].[CH:15](=[O:18])[CH2:16][CH3:17].C(O)(=O)C>CO>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[C:16]([CH3:17])[CH:15]=[O:18])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 527PropanalHCID 14797Potassium HydroxideHCID 703244-tert-Butylbenzaldehyde

생성물 1

HCID 1146592-Propenal, 3-[4-(1,1-dimethylethyl)phenyl]-2-methyl-

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

108.5 g of p-tert.butyl-benzaldehyde are added under nitrogen gasification to a solution of 1.4 g of potassium hydroxide in 100 ml of methanol and 39.2 g of propionaldehyde are subsequently added dropwise at 40° C. over a period of 6 hours. Subsequently, the mixture is further stirred at 40° C. for 1 hour, 1.5 ml of acetic acid are added and the mixture is concentrated on a rotary evaporator. The oily suspension is taken up in ether, washed neutral with water, dried and evaporated. By distillation there is obtained pure 3-(p-tert.butyl-phenyl)-2-methyl-acrolein of boiling point 165° C./11 Torr.

후처리

  1. additionare subsequently added dropwise at 40° C. over a period of 6 hours
  2. concentrationthe mixture is concentrated on a rotary evaporator
  3. washwashed neutral with water
  4. customdried
  5. customevaporated
  6. distillationBy distillation there

출처 및 근거

ORD 기록
ord-7ba3d7c254654ce5a4ed8c6e78790a40
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04241058

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