2-Propenal, 3-[4-(1,1-dimethylethyl)phenyl]-2-methyl- → 3-(4-tert-Butylphenyl)-2-methylprop-2-en-1-ol

HRID 1733273

반응식

HRID 1733273 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]=[C:12]([CH3:15])[CH:13]=[O:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[BH4-].[Na+]>CO>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]=[C:12]([CH3:15])[CH2:13][OH:14])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 1146592-Propenal, 3-[4-(1,1-dimethylethyl)phenyl]-2-methyl-HCID 4311764Sodium borohydride

생성물 1

HCID 543813673-(4-tert-Butylphenyl)-2-methylprop-2-en-1-ol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

404.5 g of 3-(p-tert.butyl-phenyl)-2-methyl-acrolein are dissolved in 2500 ml of methanol and treated portionwise with 38 g of sodium borohydride while cooling with ice. Subsequently, the mixture is stirred at room temperature for 2.5 hours, poured into 2500 ml of ice-cold 2-N hydrochloric acid and exhaustively extracted with hexane. The combined hexane extracts are washed neutral with water, dried over sodium sulphate and evaporated. Vacuum distillation yields pure 3-(p-tert.butyl-phenyl)-2-methyl-allyl alcohol of boiling point 119° C./0.005 Torr.

후처리

  1. temperaturewhile cooling with ice
  2. extractionexhaustively extracted with hexane
  3. washThe combined hexane extracts are washed neutral with water
  4. dry with materialdried over sodium sulphate
  5. customevaporated
  6. distillationVacuum distillation

출처 및 근거

ORD 기록
ord-c9b3e26ab02241aaa76378731f7f9858
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04241058

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