Hydrochloric Acid → 3-Oxo-3-(thiophen-3-yl)propanenitrile

HRID 1733304노트

반응식

HRID 1733304 반응식
N[C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)=[CH:3][C:4]#[N:5].Cl.C[OH:13]>>[O:13]=[C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[CH2:3][C:4]#[N:5]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54536012beta-Amino-3-thiopheneacrylonitrile

생성물 1

HCID 27400753-Oxo-3-(thiophen-3-yl)propanenitrile

실험 절차

A 1.2 g. portion of β-amino-3-thiopheneacrylonitrile is added to 10 ml. of 1 N hydrochloric acid. A 40 ml. portion of methanol is added and the mixture is stirred for 3 hours. The mixture is evaporated in vacuo to a residue which is dissolved in 35 ml. of hot methanol and treated with charcoal. After cooling, petroleum ether is added, the mixture is filtered and the solid collected is discarded. The filtrate is allowed to evaporate and the residue is dissolved in 35 ml. of hot isopropanol and isoluble material filtered and discarded The filtrate is cooled and the solid is collected giving the desired product as white plates, m.p. 87°-88° C.

후처리

  1. customThe mixture is evaporated in vacuo to a residue which
  2. dissolutionis dissolved in 35 ml
  3. additionof hot methanol and treated with charcoal
  4. temperatureAfter cooling
  5. additionpetroleum ether is added
  6. filtrationthe mixture is filtered
  7. customthe solid collected
  8. customto evaporate
  9. dissolutionthe residue is dissolved in 35 ml
  10. filtrationof hot isopropanol and isoluble material filtered
  11. temperatureis cooled
  12. customthe solid is collected

출처 및 근거

ORD 기록
ord-3bc6011f6acb4146adb1f9389d601cef
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04241077

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