Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N-[4-(hexadecylamino)benzoyl]-2-methylalanine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Aminoisobutyric acid | HCID 6119 | — |
| 반응물 | 4-Hexadecylaminobenzoyl chloride hydrochloride | HCID 13255322 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-[4-(hexadecylamino)benzoyl]-2-methylalanine | HCID 20437359 | — |
반응 단계
A mixture of 5.24 g. of α-aminoisobutyric acid, 50 ml. of pyridine, and 25 ml. of H2O was stirred while 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride was added. The mixture was stirred for 18 hours at ambient temperature and filtered. The filtrate was evaporated and the residual yellow glass was dissolved in 1 N NaOH solution. The solution was extracted with diethyl ether and then acidified with 6 N HCl. The precipitate was collected, dried, and recrystallized from acetone, melting point 199°-202° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04242273 |
| 출처 데이터셋 | uspto-grants-1980_12 |
| ORD ID | ord-a2a339dc721d4809a78cdb8ca5e5ee85 |
| 출처 메모 | uspto-grants-1980_12 |