Chloride → N-carbobenzyloxy-4-(hexadecylamino)benzoyl chloride

HRID 1733518

반응식

HRID 1733518 반응식
[CH2:1]([NH:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].C(Cl)(Cl)Cl.[C:31](=[O:34])([O-])[O-:32].[Na+].[Na+].[Cl-:37]>O>[C:31]([N:17]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:18]1[CH:19]=[CH:20][C:21]([C:22]([Cl:37])=[O:24])=[CH:25][CH:26]=1)([O:32][CH2:22][C:21]1[CH:25]=[CH:26][CH:18]=[CH:19][CH:20]=1)=[O:34]

참가 물질

6

반응물 4

HCID 312ChlorideHCID 6212ChloroformHCID 10340Sodium CarbonateHCID 472634-(Hexadecylamino)benzoic acid

생성물 1

HCID 20437379N-carbobenzyloxy-4-(hexadecylamino)benzoyl chloride

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

To 15 g. of 4-(n-hexadecylamino)benzoic acid in 200 ml. warm chloroform is added 15 g. sodium carbonate in 150 ml. water. To the vigorously stirred solution is added 10 g. carbobenzoyl chloride. After 2 hours stirring at 40° C., the layers are separated, washed three times with 1 N hydrochloric acid, dried, and evaporated to an oil. The oil is dissolved in 300 ml. toluene, treated with 15 ml. of thionyl chloride, and the solution is refluxed for 5 hours. The solvents are evaporated and the residue is dissolved three times in toluene, evaporating each time to yield a viscous, orange oil.

후처리

  1. additionTo the vigorously stirred solution is added 10 g
  2. customthe layers are separated
  3. washwashed three times with 1 N hydrochloric acid
  4. customdried
  5. customevaporated to an oil
  6. dissolutionThe oil is dissolved in 300 ml
  7. additiontoluene, treated with 15 ml
  8. temperatureof thionyl chloride, and the solution is refluxed for 5 hours
  9. customThe solvents are evaporated
  10. dissolutionthe residue is dissolved three times in toluene
  11. customevaporating each time
  12. customto yield a viscous, orange oil

출처 및 근거

ORD 기록
ord-333d3e277516464591b858f43f574387
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04242273

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