Hydrochloric Acid → 1-(4-Hydroxy-3-thienyl)ethanone

HRID 1733588노트

반응식

HRID 1733588 반응식
[OH:1][CH:2]1[C:6]([C:7](=[O:9])[CH3:8])=[CH:5][S:4][CH2:3]1.S(Cl)(Cl)(=O)=O.Cl>C(Cl)Cl>[OH:1][C:2]1[C:6]([C:7](=[O:9])[CH3:8])=[CH:5][S:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24648Sulfuryl chlorideHCID 20300157HCID 20300157, 화합물

생성물 1

HCID 217161-(4-Hydroxy-3-thienyl)ethanone수율 77%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2.88 parts of 3-hydroxy-4-acetyldihydrothiophene are introduced into 20 parts by volume of dried methylene chloride; a solution of 1.7 parts by volume of sulfuryl chloride in 20 parts by volume of dried methylene chloride is added in the course of 10 minutes at 0° C. During the reaction, nitrogen is passed in, in order to expel the hydrochloric acid formed. After 30 minutes, the reaction mixture is worked up. The end product is isolated from the reaction mixture by the method described in Example 1c. 2.22 parts (77% of theory) of 3-hydroxy-4-acetylthiophene of melting point 44°-47° C. are obtained.

후처리

  1. customDuring the reaction, nitrogen
  2. customformed
  3. customThe end product is isolated from the reaction mixture by the method

출처 및 근거

ORD 기록
ord-36db5b46c01244429e0eb715fea88802
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04242518

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