Trifluoromethyluracil → 5-Trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine

HRID 1734119노트

반응식

HRID 1734119 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.[CH3:13][Si:14]([CH3:17])([CH3:16])Cl>C[Si](C)(C)N[Si](C)(C)C>[F:12][C:2]([F:11])([F:1])[C:3]1[C:4]([O:10][Si:14]([CH3:17])([CH3:16])[CH3:13])=[N:5][C:6]([O:9][Si:14]([CH3:17])([CH3:16])[CH3:13])=[N:7][CH:8]=1

참가 물질

4

반응물 2

HCID 5899TrifluoromethyluracilHCID 6397Chlorotrimethylsilane

생성물 1

HCID 109909625-Trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine

시약·촉매·용매 1

HCID 13838Hexamethyldisilazane용매

실험 절차

In 50 ml of hexamethyldisilazane, 6.16 g of 5-trifluoromethyluracil was suspended and then 0.22 ml of trimethylchlorosilane was added to the suspension, followed by heating the resulting mixture to reflux for 5 hours. After the reaction, the excess hexamethyldisilazane was removed by evaporation and the resultant was distilled in vacuum. All of the fractions of distillate obtained at about 60° C. under 1 mmHg were collected. Yield: 10.3 g

후처리

  1. temperatureby heating the resulting mixture
  2. temperatureto reflux for 5 hours
  3. customAfter the reaction
  4. customthe excess hexamethyldisilazane was removed by evaporation
  5. distillationthe resultant was distilled in vacuum
  6. customAll of the fractions of distillate obtained at about 60° C. under 1 mmHg
  7. customwere collected

출처 및 근거

ORD 기록
ord-584c1ea662e0478e8b7213f4c54bf5ae
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05532349

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