Hydrochloric Acid → 2-Methoxy-4-methylpyridin-3-amine

HRID 1734121노트

반응식

HRID 1734121 반응식
C(OC([NH:8][C:9]1[C:10]([O:16][CH3:17])=[N:11][CH:12]=[CH:13][C:14]=1[CH3:15])=O)(C)(C)C.Cl>CCOC(C)=O>[NH2:8][C:9]1[C:10]([O:16][CH3:17])=[N:11][CH:12]=[CH:13][C:14]=1[CH3:15]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 10082908Tert-butyl 2-methoxy-4-methylpyridin-3-ylcarbamate

생성물 1

HCID 103293612-Methoxy-4-methylpyridin-3-amine수율 100%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3-(tert-Butoxycarbonylamino)-2-methoxy-4-methylpyridine (0.7 g, 2.9 mmol) was treated with 25 mL of 4M HCl in EtOAc at room temperature overnight. The resulting suspension was carefully washed with sat. NaHCO3, dried (MgSO4) and concentrated to give 0.4 g of the free amine as an oil (100%). m.p. (HCl salt): 199° C. (d).

후처리

  1. washThe resulting suspension was carefully washed with sat. NaHCO3
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9ff4367edf7e4ff59a9646f0405f517f
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05532358

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