Water → N-(2-Benzoylphenyl)-2-bromoacetamide

HRID 1734323

반응식

HRID 1734323 반응식
[Br:1][CH2:2][C:3](Br)=[O:4].[NH2:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].O>ClCCl>[Br:1][CH2:2][C:3]([NH:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])=[O:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 61147Bromoacetyl bromideHCID 760802-Aminobenzophenone

생성물 1

HCID 84439N-(2-Benzoylphenyl)-2-bromoacetamide수율 97.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
-5 °C

실험 절차

A solution of bromoacetyl bromide (100 mL, 1.15 mol, Aldrich) dissolved in dichloromethane (300 mL) was added over 30 min to a solution of 2-aminobenzophenone (197 g, 1.0 mol, Fluka) dissolved in dichloromethane (1.3 L) and water (100) mL) cooled to -10° C. under vigorous mechanical stirring. The resulting mixture was stirred for an additional 1 h at -5° C. and then was allowed to warm to ambient temperature. The layers were separated, and the organic extract was washed with dilute sodium bicarbonate, then was dried over sodium sulfate. Evaporation afforded 309.8 g (95%) of 2-bromoacetamidobenzophenone as off-white crystals.

후처리

  1. temperatureto warm to ambient temperature
  2. customThe layers were separated
  3. extractionthe organic extract
  4. washwas washed with dilute sodium bicarbonate
  5. dry with materialwas dried over sodium sulfate
  6. customEvaporation

출처 및 근거

ORD 기록
ord-6e118f0a3ce64569a0e2cefa1d0f7ad9
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05532359

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