Nitric Acid → HCID 19436799, 화합물

HRID 1735010노트

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][C:10]2[N:14]([CH3:15])[N:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:6]=[N:7][CH:8]=1.[N+:20]([O-])([OH:22])=[O:21].S(=O)(=O)(O)O.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][C:10]2[N:14]([CH3:15])[N:13]=[C:12]([C:16]([F:19])([F:17])[F:18])[C:11]=2[N+:20]([O-:22])=[O:21])[N:6]=[N:7][CH:8]=1

참가 물질

반응물 4

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 14798Sodium Hydroxide

HCID 19436789HCID 19436789, 화합물

생성물 1

HCID 19436799HCID 19436799, 화합물수율 99%

실험 절차

5-Methoxy-3-[[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (Compound No. 5, 1.2 g, 0.0043 mole) was added to a mixture of nitric acid (5 mL) and sulfuric acid (13 mL), and the mixture was stirred at room temperature for 18 hours. The reaction mixture was poured into ice and neutralized with 10% sodium hydroxide. Filtration gave, after drying, 5-methoxy-3-[[1-methyl-4-nitro-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (1.36 g, 99% yield) as a beige solid.

후처리

filtrationFiltration
customgave
customafter drying

출처 및 근거

ORD 기록: ord-7cf123965f1442e6a758d15a1866a81c
출처 데이터셋: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05536701

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