Nitric Acid → Isosorbide Mononitrate

HRID 1735679노트

반응식

HRID 1735679 반응식
CC([O:4][C@@H:5]1[C@H:9]2[O:10][CH2:11][C@@H:12]([OH:13])[C@H:8]2[O:7][CH2:6]1)=O.[N+:14]([O-])([OH:16])=[O:15].C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C.C(OC(=O)C)(=O)C.CO>[CH2:11]1[O:10][C@@H:9]2[C@H:5]([O:4][N+:14]([O-:16])=[O:15])[CH2:6][O:7][C@@H:8]2[C@H:12]1[OH:13]

참가 물질

7

반응물 3

HCID 944Nitric AcidHCID 11430Potassium CarbonateHCID 10856233Isosorbide-2-Acetate

생성물 1

HCID 27661Isosorbide Mononitrate

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 887Methanol용매HCID 7918Acetic Anhydride용매

실험 절차

For this isosorbide-2-acetate is for example firstly nitrated with nitric acid in glacial acetic acid or acetic acid anhydride and subsequently the acetate group is cleaved off with potassium carbonate in methanol. In this process isosorbide-5-nitrate is obtained in an isomerically pure form and in excellent yield (FIG. 1).

출처 및 근거

ORD 기록
ord-5c0e6cbd81b24705889798c2a33ccf82
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05538891

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