Sodium Hydroxide → 5-amino-2-(4-carboxymethylamino-3-fluorophenyl)-6,8-difluoro-4H-1-benzopyran-4-one

HRID 1736119노트

반응식

HRID 1736119 반응식
[OH-].[Na+].C([N:6]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]3[C:29]([F:30])=[CH:28][C:27]([F:31])=[C:26]([NH2:32])[C:22]=3[C:23](=[O:25])[CH:24]=2)=[CH:15][C:14]=1[F:33])[CH2:7][C:8]([O:10]CC)=[O:9])(=O)C>C(O)C>[NH2:32][C:26]1[C:22]2[C:23](=[O:25])[CH:24]=[C:19]([C:16]3[CH:17]=[CH:18][C:13]([NH:6][CH2:7][C:8]([OH:10])=[O:9])=[C:14]([F:33])[CH:15]=3)[O:20][C:21]=2[C:29]([F:30])=[CH:28][C:27]=1[F:31]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19434923HCID 19434923, 화합물

생성물 1

HCID 194348155-amino-2-(4-carboxymethylamino-3-fluorophenyl)-6,8-difluoro-4H-1-benzopyran-4-one수율 102.3%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

30 ml ethanol and 4.3 ml of a 2N aqueous solution of sodium hydroxide were added to 560 mg (1.43 mmol) of Compound 44 obtained in Example 44 and the mixture was stirred at 50° C. for 10 minutes. The reaction solution was cooled to room temperature and the precipitated crystals were collected by filtration to give 533 mg (97%) of Compound 45.

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-85d5bb6bd4324dda9f2f0ee91ed22327
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05539112

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