2-Benzylidenecyclohexanone → HCID 12118799, 화합물

HRID 1737175노트

반응식

HRID 1737175 반응식
[CH:1](=[C:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni].CO>[CH2:1]([C@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:1]([C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 1

HCID 989262-Benzylidenecyclohexanone

생성물 2

HCID 12118799HCID 12118799, 화합물수율 88%HCID 12283992Cyclohexanol, 2-(phenylmethyl)-, cis-

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

Then, 10 g of 2-benzylidenecyclohexanone were hydrogenated at room temperature using 1 g of Raney nickel in methanol under hydrogen pressure (3 kg/cm2) until the absorption of hydrogen was stopped. After an organic layer was collected by decantation and concentrated, the residue was purified by column chromatography, thereby obtaining 4.6 g of cis-2-benzylcyclohexanol and 4.4 g of trans-2-benzylcyclohexanol (yield: 88% in total).

후처리

  1. customwere hydrogenated at room temperature
  2. customuntil the absorption of hydrogen
  3. customAfter an organic layer was collected by decantation
  4. concentrationconcentrated
  5. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-66b69874a6dd4b8db91e126567b090d3
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05962403

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