Thionyl Chloride → 2-(2-Chloroethylthio)-1-methylimidazole hydrochloride

HRID 1737578노트

반응식

HRID 1737578 반응식
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][S:8][C:9]1[N:10]([CH3:14])[CH:11]=[CH:12][N:13]=1>ClC(Cl)Cl>[ClH:3].[Cl:3][CH2:6][CH2:7][S:8][C:9]1[N:10]([CH3:14])[CH:11]=[CH:12][N:13]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 27748452-[(1-methyl-1H-imidazol-2-yl)thio]ethan-1-ol

생성물 1

HCID 226249432-(2-Chloroethylthio)-1-methylimidazole hydrochloride수율 246.9%

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
5 °C

실험 절차

Thionyl chloride (1.41 ml, 19 mmol) was slowly added to a solution of 2-(2-hydroxyethylthio)-1-methylimidazole (1.81 g, 11 mmol) in trichloromethane (20 ml) at 5° C. The mixture was stirred for 1 hour at 5° C. and then for 3 hours at ambient temperature. The volatiles were removed by evaporation and the residue azeotroped with toluene to give 2-(2-chloroethylthio)-1-methylimidazole hydrochloride (l.5 g, 77%).

후처리

  1. waitfor 3 hours at ambient temperature
  2. customThe volatiles were removed by evaporation
  3. customthe residue azeotroped with toluene

출처 및 근거

ORD 기록
ord-21e583745b23488e9666d53fef7d33b2
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05962458

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