5-Bromo-2-[2-(4-methoxyphenyl)vinyl]benzofuran → 5-Bromo-2-[2-(4-methoxyphenyl)ethyl]benzofuran

HRID 1738683노트

반응식

HRID 1738683 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]=[CH:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)=[CH:7][C:6]=2[CH:20]=1>O1CCCC1.C(O)C.[Pt](=O)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)=[CH:7][C:6]=2[CH:20]=1

참가 물질

5

반응물 1

HCID 537809305-Bromo-2-[2-(4-methoxyphenyl)vinyl]benzofuran

생성물 1

HCID 218443105-Bromo-2-[2-(4-methoxyphenyl)ethyl]benzofuran수율 75.4%

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

128 g of 5-bromo-2-[2-(4-methoxyphenyl)vinyl]benzofuran as a mixture of two stereoisomers was dissolved in a solvent mixture of 1.3 l of tetrahydrofuran and 0.7 l of ethanol. The resulting solution was mixed with 3.0 g of platinum dioxide and subjected to 4 hours of catalytic hydrogenation under normal pressure. Thereafter, the catalyst was removed by filtration, the resulting filtrate was concentrated, and crystals thus precipitated were collected by filtration and washed with ethanol. In this way, 97.08 g of 5-bromo-2-[2-(4-methoxyphenyl)ethyl]benzofuran was obtained.

후처리

  1. customThereafter, the catalyst was removed by filtration
  2. concentrationthe resulting filtrate was concentrated
  3. customcrystals thus precipitated
  4. filtrationwere collected by filtration
  5. washwashed with ethanol

출처 및 근거

ORD 기록
ord-61baa9083f88402198f2e4ed6d67c93d
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05962695

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