Hydrochloric Acid → HCID 21840019, 화합물

HRID 1739012노트

반응식

HRID 1739012 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[CH:21]=2)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:10](=[O:27])[CH2:9]1)=O)(C)(C)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[O:27]=[C:10]1[C:11]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH3:26])[CH:21]=2)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 54555641HCID 54555641, 화합물

생성물 1

HCID 21840019HCID 21840019, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a cold (0° C.) solution of ethyl N-tert-butoxycarbonyl-3-oxo-4-(3-methylbenzyl)piperidine-4-carboxylate (1.55 g, 4.13 mmol) in ethyl acetate (75 mL), a stream of anhydrous hydrogen chloride gas was bubbled for 20 min. The resultant mixture was stirred at 0° C. for 1 h, purged with argon for 10 min., and concentrated under vacuum to provide the title compound as white solid.

후처리

  1. custompurged with argon for 10 min.
  2. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-c40320dd57a642adb3ef197b03481f29
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05965578

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