Hydrazine hydrate (1:1) → 2-Bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine

HRID 1739429노트

반응식

HRID 1739429 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:8]([C:13](=O)[C:14]2[CH:19]=[CH:18][N:17]=[C:16]([Br:20])[CH:15]=2)=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=O.O.[NH2:23][NH2:24]>CO>[Br:20][C:16]1[CH:15]=[C:14]([C:13]2[C:8]3[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:10]([O:11][CH3:12])[CH:9]=3)[CH:6]=[N:24][N:23]=2)[CH:19]=[CH:18][N:17]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 218408403,4-Dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde

생성물 1

HCID 218408262-Bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3,4-dimethoxy-6-(2-bromoisonicotinoyl)benzaldehyde (4.5 g) in methanol (70 ml) is added dropwise hydrazine monohydrate (0.8 ml). The reaction mixture is cooled with ice, and the precipitates are collected by filtration, and recrystallized from methanol to give 2-bromo-4-(6,7-dimethoxyphthalazin-1-yl)pyridine (4.01 g) as yellow crystals.

후처리

  1. temperatureThe reaction mixture is cooled with ice
  2. filtrationthe precipitates are collected by filtration
  3. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-daa5282d355343339542882c9bf68cc2
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05965730

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