2-Hydroxy-5-methylbenzyl alcohol → Benzaldehyde, 2-hydroxy-5-methyl-

HRID 1739486

반응식

HRID 1739486 반응식
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:4]=1[OH:10]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[OH:10][C:4]1[CH:5]=[CH:6][C:7]([CH3:9])=[CH:8][C:3]=1[CH:2]=[O:1]

참가 물질

4

반응물 1

HCID 2574522-Hydroxy-5-methylbenzyl alcohol

생성물 1

HCID 69184Benzaldehyde, 2-hydroxy-5-methyl-수율 20.7%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

2-Hydroxymethyl-4-methylphenol (3.1 g, 22.4 mMol) was dissolved in CHCl3 (95 ml). The solution was treated with manganese dioxide (8.7 g, 100 mmol) and the reaction stirred at ambient temperature overnight under an argon atmosphere. The reaction was then filtered through Celite and the solvent evaporated. The residue was subjected to chromatography (eluant: ethyl ether/hexane) to give 2-hydroxy-5-methylbenzaldehyde as a pale green solid (0.63 g, 20.7%).

후처리

  1. filtrationThe reaction was then filtered through Celite
  2. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-d860a9483f7040eca836722a1bc22f20
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05965741

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