Hydrochloric Acid → HCID 54500756, 화합물

HRID 1740493노트

반응식

HRID 1740493 반응식
[F:1][C:2]([F:15])([F:14])[S:3]([O:6]S(C(F)(F)F)(=O)=O)(=[O:5])=[O:4].[CH3:16][O:17][CH2:18][C@@H:19]1[O:23][C:22](=[O:24])[N:21]([C:25]2[C:29]3[CH:30]=[CH:31][C:32](O)=[CH:33][C:28]=3[O:27][CH:26]=2)[CH2:20]1.Cl>N1C=CC=CC=1>[F:1][C:2]([F:15])([F:14])[S:3]([O:6][C:32]1[CH:31]=[CH:30][C:29]2[C:25]([N:21]3[CH2:20][C@H:19]([CH2:18][O:17][CH3:16])[O:23][C:22]3=[O:24])=[CH:26][O:27][C:28]=2[CH:33]=1)(=[O:5])=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 67749Trifluoromethanesulfonic anhydrideHCID 15381150HCID 15381150, 화합물

생성물 1

HCID 54500756HCID 54500756, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5.8 ml (0.035 mol) of trifluoromethanesulphonic anhydride are added slowly to a solution, maintained at -20° C., of 7.6 g (0.029 mol) of (R)-5-(methoxymethyl)-3-(6-hydroxybenzofuran-3-yl)oxazolidin-2-one in 60 ml of pyridine. After returning to room temperature, the mixture is poured into ice and is brought to a pH of 6 by means of 2N hydrochloric acid. The product is then extracted with ethyl acetate, the solvent is evaporated under reduced pressure and the product is purified by chromatography on silica gel with a 10/90 mixture of cyclohexane and dichloromethane.

후처리

  1. customAfter returning to room temperature
  2. additionthe mixture is poured into ice
  3. extractionThe product is then extracted with ethyl acetate
  4. customthe solvent is evaporated under reduced pressure
  5. customthe product is purified by chromatography on silica gel with a 10/90 mixture of cyclohexane and dichloromethane

출처 및 근거

ORD 기록
ord-0449bb5862384ee4875dbae51f03aa08
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05969146

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