Hydrochloric Acid → N-(4-Formyl-2-pyrimidinyl)acetamide

HRID 1740577노트

반응식

HRID 1740577 반응식
C[O-].[Na+].C(O[O:8][CH:9](OC)[C:10]1[CH:15]=[CH:14][N:13]=[C:12]([NH:16][C:17](=[O:19])[CH3:18])[N:11]=1)(=O)C.Cl>CO>[C:17]([NH:16][C:12]1[N:11]=[C:10]([CH:9]=[O:8])[CH:15]=[CH:14][N:13]=1)(=[O:19])[CH3:18]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 22002535HCID 22002535, 화합물

생성물 1

HCID 17840022N-(4-Formyl-2-pyrimidinyl)acetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium methoxide (0.056 g, 1.0 mmol) was added to a solution of 2-acetamido-pyrimidine-4-carboxaldehyde monomethyl monoacetoxy acetal (5.0 g, 21 mmol) in MeOH (25 mL) at ambient temperature. After stirring at this temperature for 3 h, the reaction mixture was neutralized by addition of 3N HCl. The resulting solution was concentrated and the residue was treated with CH2Cl2. Remaining solids were removed by filtration and the solvent was evaporated to afford the title compound as a yellow solid; yield 3.2 g (92%).

후처리

  1. concentrationThe resulting solution was concentrated
  2. additionthe residue was treated with CH2Cl2
  3. customwere removed by filtration
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-e1d9d2db4aec4fe08a192640b56b3df1
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05969184

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