Phosphorus tribromide → 1-(Bromomethyl)-4-methoxycyclohexane

HRID 1740703

반응식

HRID 1740703 반응식
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([CH2:9]O)[CH2:5][CH2:4]1.P(Br)(Br)[Br:12]>C(Cl)(Cl)(Cl)Cl>[Br:12][CH2:9][CH:6]1[CH2:7][CH2:8][CH:3]([O:2][CH3:1])[CH2:4][CH2:5]1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 18533153(4-Methoxycyclohexyl)methanol

생성물 1

HCID 217065291-(Bromomethyl)-4-methoxycyclohexane

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

4-Methoxycyclohexylmethanol (10.5 g) was dissolved in carbon tetrachloride (45 g) and cooled with ice. Phosphorus tribromide (2.8 ml) was added dropwise to the above solution and stirred at ambient temperature overnight. The carbon tetrachloride layer was decanted and dried over magnesium sulfate. After filtering, the carbon tetrachloride from the filtrate was evaporated to yield pale yellow colored liquid of bromomethyl-4-methoxycyclohexane.

후처리

  1. temperaturecooled with ice
  2. customThe carbon tetrachloride layer was decanted
  3. dry with materialdried over magnesium sulfate
  4. filtrationAfter filtering
  5. customthe carbon tetrachloride from the filtrate was evaporated

출처 및 근거

ORD 기록
ord-1090d29d562a414b84259e233b957a84
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05972552

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