Trimethylsilyldiazomethane → Methyl 2-acetamidoisonicotinate

HRID 1740946

반응식

HRID 1740946 반응식
[C:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([NH:10][C:11](=[O:13])[CH3:12])[CH:5]=1)([OH:3])=[O:2].[Si](C=[N+]=[N-])(C)(C)[CH3:15]>CO.C1C=CC=CC=1>[CH3:15][O:2][C:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([NH:10][C:11](=[O:13])[CH3:12])[CH:5]=1)=[O:3]

참가 물질

4

반응물 2

HCID 167693TrimethylsilyldiazomethaneHCID 37744662-Acetamidopyridine-4-carboxylic acid

생성물 1

HCID 22185175Methyl 2-acetamidoisonicotinate

시약·촉매·용매 1

HCID 21927730Benzene methanol용매

실험 절차

4-Carboxy-2-acetylaminopyridine (3.4 g, 19 mmol) was dissolved in methanol/benzene (100 mL, 1:1). TMS-diazomethane was added (1M, Aldrich) with cooling until the yellow color just persisted, then the solvent was removed under reduced pressure. The product was purified by silica gel column chromatography (50/50 hexane/ethyl acetate) and 3.0 g of product was recovered.

후처리

  1. temperaturewith cooling until the yellow color
  2. customthe solvent was removed under reduced pressure
  3. customThe product was purified by silica gel column chromatography (50/50 hexane/ethyl acetate) and 3.0 g of product
  4. customwas recovered

출처 및 근거

ORD 기록
ord-5841a4b889fc4ec4832020a9bd18915c
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05972975

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