Hydrazine hydrate (1:1) → 2-Naphthohydrazide

HRID 1741142

반응식

HRID 1741142 반응식
C([O:3][C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1)=O)C.O.[NH2:17][NH2:18]>C(O)C>[CH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:14]=[CH:15][C:6]=1[C:4]([NH:17][NH2:18])=[O:3]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 76363Ethyl 2-naphthoate

생성물 1

HCID 1234852-Naphthohydrazide수율 48.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2-naphthyl carboxylic acid ethyl ester (2.0 g, 9.99 mmol) in absolute ethanol (30 ml) was added hydrazine hydrate (4.85 ml, 99.9 mmol) and the reaction mixture was heated at reflux temperature for 72 h. The reaction mixture was cooled and the precipitate was filtered off, washed with 96% ethanol (2×10 ml) and diethyl ether (3×10 ml), dried in vacuo at 50° C. which afforded 0.9 g (48%) of naphthalene-2-carboxylic acid hydrazide as a solid.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux temperature for 72 h
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe precipitate was filtered off
  5. washwashed with 96% ethanol (2×10 ml) and diethyl ether (3×10 ml)
  6. customdried in vacuo at 50° C. which

출처 및 근거

ORD 기록
ord-d30aaf54840242e5be9c7684853fff69
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05972978

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