Hydrochloric Acid → 4-Chloro-N,N-dimethylbenzamide
반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH3:11][NH:12][CH3:13].N1C=CC=CC=1.Cl>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:12]([CH3:13])[CH3:11])=[O:7])=[CH:4][CH:3]=1참가 물질
6
실험 절차
The procedure of Example 13 is followed, but the endcapper is 4-chloro-N,N-dimethylbenzamide (0.20 g, 1.09 mmol) to yield the amido-functionalized macromonomer. 4-Chloro-N,N-dimethylbenzamide is prepared by reacting 4-chlorobenzoyl chloride with dimethylamine in toluene with some pyridine (1 mol equivalent per acid chloride) to trap the HCl that is evolved. After aqueous extraction of the pyridinium salt and any excess starting materials, the product is crystallized from the toluene solution.
후처리
- extractionAfter aqueous extraction of the pyridinium salt
- customany excess starting materials, the product is crystallized from the toluene solution
출처 및 근거
- ORD 기록
- ord-ffdaacb215e94d45b495d3fe760774c5
- 출처 데이터셋
- uspto-grants-1999_10
- 특허 번호
- US05973075
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