Hydrochloric Acid → Urea, (2-hydroxy-4-methylphenyl)-
반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[CH:6][C:7]=1[OH:8].[NH2:10][C:11](N)=[O:12].Cl>O.C(O)(=O)C>[OH:8][C:7]1[CH:6]=[C:5]([CH3:9])[CH:4]=[CH:3][C:2]=1[NH:1][C:11]([NH2:10])=[O:12]참가 물질
6
실험 절차
To 13 ml of water, there were added 5.00 g (40.7 mmol) of 6-amino-m-cresol, 9.76 g of (162.6 mmol) of urea, 4 ml of conc. hydrochloric acid and 0.8 ml of a mixture (1:1 (v:v)) of conc. hydrochloric acid and glacial acetic acid, followed by heating under reflux for 1.5 hours. After cooling, 20 ml of water was added. The crystals thus precipitated were filtered and dried to thereby give 5.81 g (35.0 mmol) of N-(2-hydroxy-4-methylphenyl)urea as dark brown crystals. The yield was 86%. After recrystallizing from acetonitrile, 2.00 g of N-(2-hydroxy-4-methylphenyl)urea was obtained as pale purple crystals. The recovering yield was 34%.
후처리
- temperatureby heating
- temperatureunder reflux for 1.5 hours
- temperatureAfter cooling
- customThe crystals thus precipitated
- filtrationwere filtered
- customdried
출처 및 근거
- ORD 기록
- ord-bf95338779ae475fa9c9bc341d2d4a05
- 출처 데이터셋
- uspto-grants-1994_08
- 특허 번호
- US05334225
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