Acetone → N-(2-hydroxy-4-methylphenyl)-3-aminopropionamide hydrochloride

HRID 1741541

반응식

HRID 1741541 반응식
[ClH:1].CC(C)=O.[OH:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:8]=1[NH:14][C:15](=[O:26])[CH2:16][CH2:17][NH:18]C(OC(C)(C)C)=O>CCOCC>[ClH:1].[OH:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:8]=1[NH:14][C:15](=[O:26])[CH2:16][CH2:17][NH2:18]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 19010153N-(2-hydroxy-4-methylphenyl)-3-(tert-butoxycarbonyl)aminopropionamide

생성물 1

HCID 19010160N-(2-hydroxy-4-methylphenyl)-3-aminopropionamide hydrochloride수율 59%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 15 ml of a saturated solution of hydrogen chloride in ether, there were added 10 ml of acetone and 1.30 g (4.4 mmol) of N-(2-hydroxy-4-methylphenyl)-3-(tert-butoxycarbonyl)aminopropionamide and stirred at room temperature for 30 minutes. After the completion of the reaction, the crystals thus precipitated were filtered, washed with ether and dried. Thus 0.76 g (2.6 mmol) of N-(2-hydroxy-4-methylphenyl)-3-aminopropionamide hydrochloride was obtained. The yield was 59%.

후처리

  1. customAfter the completion of the reaction
  2. customthe crystals thus precipitated
  3. filtrationwere filtered
  4. washwashed with ether
  5. customdried

출처 및 근거

ORD 기록
ord-05d22f97225c4225b0961ba05bf34395
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05334225

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