Methanol → 5'-Chloro-2'-hydroxy-P-acetotoluidide

HRID 1741546

반응식

HRID 1741546 반응식
CO.[NH2:3][C:4]1[CH:9]=[C:8]([Cl:10])[C:7]([CH3:11])=[CH:6][C:5]=1[OH:12].[C:13](OC(=O)C)(=[O:15])[CH3:14]>O>[Cl:10][C:8]1[C:7]([CH3:11])=[CH:6][C:5]([OH:12])=[C:4]([NH:3][C:13](=[O:15])[CH3:14])[CH:9]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 7918Acetic AnhydrideHCID 1045242-Amino-4-chloro-5-methylphenol

생성물 1

HCID 36474595'-Chloro-2'-hydroxy-P-acetotoluidide수율 70.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 30 ml of methanol, there were added 1.0 g (6.4 mmol) of 2-amino-4-chloro-5-methylphenol and 0.71 g (7.0 mmol) of acetic anhydride and stirred at room temperature for 30 minutes. To this solution, there was added 60 ml of water. The crystals thus precipitated were filtered and recrystallized from methanol. Thus 0.89 g (4.5 mmol) of N-(5-chloro-2-hydroxy-4-methylphenyl)acetamide was obtained as pale brown crystals. The yield was 70%.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere filtered
  3. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-6ea64157d7f44c07b91511244cb404d4
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05334225

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