N-bromobutanimide → Methyl 2-[2-(bromomethyl)phenyl]-2-oxoacetate

HRID 1741575노트

반응식

HRID 1741575 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:13])[C:9]([O:11][CH3:12])=[O:10].[Br:14]N1C(=O)CCC1=O>ClC(Cl)(Cl)Cl>[Br:14][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:13])[C:9]([O:11][CH3:12])=[O:10]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 3768392Methyl (2-methylphenyl)(oxo)acetate

생성물 1

HCID 14697242Methyl 2-[2-(bromomethyl)phenyl]-2-oxoacetate수율 49.3%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

5.34 g (30 millimoles) of methyl 2-methylphenylglyoxylate and 5.34 g (30 millimoles) of N-bromosuccinimide in 1000 l of tetrachloromethane are exposed to a 300 W Hg vapor lamp for one hour. The organic phase is then washed once with water and three times with sodium bicarbonate solution and is dried over sodium sulfate/sodium carbonate. After the solution has been evaporated down, the crude product is chromatographed over silica gel using 1:9 methyl tert-butyl ether/n-hexane. 3.8 g (49%) of the abovementioned compound are obtained as a yellow oil.

후처리

  1. washThe organic phase is then washed once with water and three times with sodium bicarbonate solution
  2. dry with materialis dried over sodium sulfate/sodium carbonate
  3. customAfter the solution has been evaporated down
  4. customthe crude product is chromatographed over silica gel using 1:9 methyl tert-butyl ether/n-hexane

출처 및 근거

ORD 기록
ord-4885aec6e7d94fe3845f77ff0c8b4b9c
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05334577

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