Isobutylbenzene → 4'-Isobutylhexanophenone

HRID 1741816

반응식

HRID 1741816 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)(=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[CH2:13]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH:14]([CH3:16])[CH3:15]>ClCCl>[CH2:13]([C:17]1[CH:22]=[CH:21][C:20]([C:5](=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[CH:19][CH:18]=1)[CH:14]([CH3:16])[CH3:15]

참가 물질

5

반응물 3

HCID 10870IsobutylbenzeneHCID 67340Hexanoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 108790194'-Isobutylhexanophenone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a suspension of aluminum chloride (6.67 g) in dichloromethane (70 ml) was added hexanoyl chloride (7.0 ml) at 0° C. After the mixture was stirred at 0° C. for 15 minutes, isobutylbenzene (7.9 ml) was added to the mixture. The mixture was stirred at 0° C. for 30 minutes and poured into ice water. The organic layer was washed with water, aqueous sodium bicarbonate and brine. The solution was dried over magnesium sulfate and evaporated to give 4'-isobutylhexanophenone (10.52 g) as a colorless oil.

후처리

  1. stirringThe mixture was stirred at 0° C. for 30 minutes
  2. washThe organic layer was washed with water, aqueous sodium bicarbonate and brine
  3. dry with materialThe solution was dried over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-af47f5de3b80488b99e32313671bce86
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05334716

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