Sodium Hydroxide → HCID 11734695, 화합물

HRID 1741849노트

반응식

HRID 1741849 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([NH:22][C:23]2[CH:24]=[C:25]([CH:45]=[CH:46][CH:47]=2)[C:26]([C:28]2[CH:29]=[C:30]([CH2:37][CH2:38][CH2:39][C:40]([O:42]CC)=[O:41])[N:31]3[C:36]=2[CH:35]=[CH:34][CH:33]=[CH:32]3)=[O:27])[C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Na+]>C(O)C>[CH2:18]([C:15]1[CH:14]=[CH:13][C:12]([CH:11]([NH:22][C:23]2[CH:24]=[C:25]([CH:45]=[CH:46][CH:47]=2)[C:26]([C:28]2[CH:29]=[C:30]([CH2:37][CH2:38][CH2:39][C:40]([OH:42])=[O:41])[N:31]3[C:36]=2[CH:35]=[CH:34][CH:33]=[CH:32]3)=[O:27])[C:8]2[CH:7]=[CH:6][C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:10][CH:9]=2)=[CH:17][CH:16]=1)[CH:19]([CH3:20])[CH3:21]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 11072251Ethyl 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyrate

생성물 1

HCID 11734695HCID 11734695, 화합물수율 85.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]-butyrate (279 mg) in ethanol (10 ml) was added 4N sodium hydroxide (0.44 ml). Stirring was continued for 1 hour at 40° C. The reaction mixture was evaporated in vacuo, then added a solution of potassium dihydrogen phosphate (300 mg) in water and 1N hydrochloric acid (26 ml), and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate. After evaporation of the solvent, the residue was chromatographed on silica gel eluting with ethyl acetate to give 4-[1-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]indolizin-3-yl]butyric acid (229 mg).

후처리

  1. customThe reaction mixture was evaporated in vacuo
  2. additionadded a solution of potassium dihydrogen phosphate (300 mg) in water and 1N hydrochloric acid (26 ml)
  3. extractionextracted with ethyl acetate
  4. dry with materialThe combined organic layers were dried over sodium sulfate
  5. customAfter evaporation of the solvent
  6. customthe residue was chromatographed on silica gel eluting with ethyl acetate

출처 및 근거

ORD 기록
ord-7f0f3c348cd740c1a6e3db3c78351091
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05334716

반응 노트

불러오는 중…