Hydrochloric Acid → Azetidine-3-carbonyldimethylamide hydrochloride

HRID 17420노트

반응식

HRID 17420 반응식
C([N:14]1[CH2:17][CH:16]([C:18]([CH2:20][N-:21][CH3:22])=[O:19])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:23]>C(O)C.[C].[Pd]>[ClH:23].[NH:14]1[CH2:17][CH:16]([C:18]([CH2:20][N-:21][CH3:22])=[O:19])[CH2:15]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 866308481-Benzhydrylazetidine-3-carbonyldimethylamide

생성물 1

HCID 86630847Azetidine-3-carbonyldimethylamide hydrochloride

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

1-Benzhydrylazetidine-3-carbonyldimethylamide (I-144) (0.24 g, 0.82 mmol) was dissolved in ethanol (10 ml), then 1 N hydrochloric acid (0.90 m, 0.90 mmol) and 10% palladium-carbon (containing about 50% water, 0.10 g) were added, followed by stirring under hydrogen atmosphere for 16 hours. The catalyst was removed by filtration, the solvent was evaporated away under reduced pressure to obtain a mixture containing the entitled compound (0.25 g). This was used in the next reaction as it was.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated away under reduced pressure
  3. customto obtain a mixture
  4. customThis was used in the next reaction as it

출처 및 근거

ORD 기록
ord-e8db50c7cb1f455197f28eeffe1f0720
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

반응 노트

불러오는 중…