Tramadol → Desmetramadol

HRID 1742028

반응식

HRID 1742028 반응식
[CH3:1][N:2]([CH2:4][C@@H:5]1[C@@:10]([OH:19])([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17]C)[CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:3].CN(C[C@H]1[C@](O)(C2C=CC=C(OC)C=2)CCCC1)C>CCO>[CH3:3][N:2]([CH2:4][C@@H:5]1[C@@:10]([OH:19])([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([OH:17])[CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:1]

참가 물질

4

반응물 2

HCID 33741TramadolHCID 667511(-)-(S,S)-trans-Tramadol

생성물 1

HCID 9838803Desmetramadol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To prepare the (+) enantiomer of the title compound, the reaction was run under the same conditions except that (+)-tramadol as the free base was used instead of the (-)-tramadol to yield 2.8 g of the (+) enantiomer of O-desmethyl tramadol (mp. 242°-3° C.) [α]D25 =+32.2 (C=1, EtOH).

출처 및 근거

ORD 기록
ord-6fa8701eeca94b1196e05d5011e511a9
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05336691

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