Acetic Anhydride → HCID 22755584, 화합물
반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[O:11]=[C:7]1[C:8]2[C:4](=[CH:3][C:2]([O:1][C:12](=[O:14])[CH3:13])=[CH:10][CH:9]=2)[CH2:5][CH2:6]1참가 물질
4
실험 절차
To a solution of 5-hydroxy-indan-1-one (1600 mg, 10.8 mmol)in CH2Cl2 (20 mL) at 23° C. were added 4-N,N-dimethylaminopyridine (1830 mg, 15 mmol) and acetic anhydride (1500 mg, 1.4 mL, 15 mmol). The reaction mixture was stirred for 25 hours, quenched with 10% hydrochloric acid (HCl) (20 mL) and diluted with CHCl3 (500 mL). The organic layer was separated and washed with saturated aqueous NaHCO3 (20 mL), dried (MgSO4)and concentrated in vacuo. 1H NMR (250 MHz, CDCl3): d 7.78 (d, 2 H), 7.21 (s, 1 H), 7.10 (d, 1 H), 3.28 (t, 2 H), 2.75 (t, 2 H), 2.38 (s, 3 H).
후처리
- customquenched with 10% hydrochloric acid (HCl) (20 mL)
- additiondiluted with CHCl3 (500 mL)
- customThe organic layer was separated
- washwashed with saturated aqueous NaHCO3 (20 mL), dried (MgSO4)and
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-ccc6c823affb4316b18a9da832488e97
- 출처 데이터셋
- uspto-grants-1994_08
- 특허 번호
- US05338740
반응 노트
불러오는 중…