Sodium Carbonate → 4-(2-Bromoethyl)-1,2-dimethylbenzene

HRID 1742711노트

반응식

HRID 1742711 반응식
P(Br)(Br)[Br:2].[CH3:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[CH2:9][CH2:10]O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)(Cl)Cl.O>[CH3:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[CH2:9][CH2:10][Br:2]

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 24614Phosphorus tribromideHCID 339432-(3,4-Dimethylphenyl)ethanol

생성물 1

HCID 225073204-(2-Bromoethyl)-1,2-dimethylbenzene

시약·촉매·용매 2

HCID 962Water용매HCID 5943Carbon Tetrachloride용매

실험 절차

Phosphorus tribromide (0.82 g) was added dropwise to a solution of 3,4-dimethylphenethyl alcohol (1.27 g--see Preparation 17) in carbon tetrachloride (10 ml). The mixture was heated under reflux for 2.5 hours then cooled to room temperature and basified (pit 8) by the dropwise addition of 10% aqueous sodium carbonate (5 ml). The mixture was then diluted with water (20 ml) and extracted with dichloromethane (3×50 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give the title compound as a colourless oil, yield, 0.5g.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 2.5 hours
  3. extractionextracted with dichloromethane (3×50 ml)
  4. dry with materialThe combined dichloromethane extracts were dried (MgSO4)
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-908ce39a84834261a6c3f1b81c199a4a
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05340831

반응 노트

불러오는 중…