Sodium Hydroxide → (S)-(-)-2-Nitro-1-(2-oxiranylmethyl)-1H-imidazole

반응식

Cl[CH2:2][C@@H:3]([OH:13])[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[C:6]1[N+:10]([O-:12])=[O:11].[OH-].[Na+]>>[N+:10]([C:6]1[N:5]([CH2:4][C@H:3]2[CH2:2][O:13]2)[CH:9]=[CH:8][N:7]=1)([O-:12])=[O:11]

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 11052772(S)-(+)-alpha-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

생성물 1

HCID 11768967(S)-(-)-2-Nitro-1-(2-oxiranylmethyl)-1H-imidazole수율 65.1%

실험 절차

Alternatively, reaction of 0.56 g of (S)-(+)-α-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol with 3 mL of 10% aqueous sodium hydroxide at 25° C. for 30 minutes followed by further processing as above gives 0.3 g of the product.

출처 및 근거

ORD 기록: ord-ee629ca523f043eface042db9a9dcc2b
출처 데이터셋: uspto-grants-1994_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05342959

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